Christine Queitisch’s research focuses on two related fields: the genetic architecture of complex traits and the role of gene regulation and protein folding in generating heritable phenotypic variation. She advances complex trait genetics by ascertaining uncharacterized sequence variation and by resolving the relative importance of additive variation and epistasis in complex traits. Lastly, to improve the genotype- phenotype map, she envisions molecular markers, applicable in any organism, that predict the penetrance of genetic variants in a given individual.